Structure Database (LMSD)

Common Name
SM(d18:1/22:0)
Systematic Name
N-(docosanoyl)-sphing-4-enine-1-phosphocholine
Synonyms
  • C22 Sphingomyelin
LM ID
LMSP03010006
Formula
C45H91N2O6P
Exact Mass
Calculate m/z
786.661476
Sum Composition
SM 40:1;O2
Abbrev Chains
SM 18:1;O2/22:0
Status
Curated
Show lipids differing only in stereochemistry/bond geometry
View NP-MRD ID(NMR) spectrum

Classification

Category
Main Class
Sub Class
Sphingolipids [SP]
Phosphosphingolipids [SP03]
Ceramide phosphocholines (sphingomyelins) [SP0301]

Biological Context

C22 Sphingomyelin is a naturally occurring form of sphingomyelin . Plasma levels of C22 sphingomyelin positively correlate with hepatic steatosis severity in patients with chronic hepatitis C virus (HCV).1 C22 Sphingomyelin levels are decreased in T-47D mammary epithelial cells and increased in MDA-MB-231 breast cancer cells relative to C16 sphingomyelin .2 As this product is derived from a natural source, there may be variations in the sphingoid backbone.[Matreya, LLC. Catalog No. 1918]

This information has been provided by Cayman Chemical

References

1. Li, J.F., Qu, F., Zheng, S.J., et al. Elevated plasma sphingomyelin (d18:1/22:0) is closely related to hepatic steatosis in patients with chronic hepatitis C virus infection. Eur. J. Clin. Microbiol. Infect. Dis. 33(10), 1725-1732 (2014).
2. Dória, M.L., Cotrim, C.Z., Simões, C., et al. Lipidomic analysis of phospholipids from human mammary epithelial and breast cancer cell lines. J. Cell. Physiol. 228(2), 457-468 (2013).

Reactions

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Reactions graph legend

References

Taxonomy Information

Curated from
NCBI taxonomy class
Reference
Homo sapiens (#9606)
Mammalia (#40674)
Lipidomics reveals a remarkable diversity of lipids in human plasma,
J Lipid Res, 2010
Pubmed ID: 20671299

String Representations

InChiKey (Click to copy)
FJJANLYCZUNFSE-TWKUQIQBSA-N
InChi (Click to copy)
InChI=1S/C45H91N2O6P/c1-6-8-10-12-14-16-18-20-21-22-23-24-25-27-29-31-33-35-37-39-45(49)46-43(42-53-54(50,51)52-41-40-47(3,4)5)44(48)38-36-34-32-30-28-26-19-17-15-13-11-9-7-2/h36,38,43-44,48H,6-35,37,39-42H2,1-5H3,(H-,46,49,50,51)/b38-36+/t43-,44+/m0/s1
SMILES (Click to copy)
[C@](COP(=O)([O-])OCC[N+](C)(C)C)([H])(NC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

Other Databases

HMDB ID
HMDB0012103
CHEBI ID
74532
PubChem CID
44260125
SwissLipids ID
SLM:000389815
Cayman ID
24451

Calculated Physicochemical Properties

Heavy Atoms 54
Rings 0
Aromatic Rings 0
Rotatable Bonds 42
Van der Waals Molecular Volume 876.35
Topological Polar Surface Area 107.92
Hydrogen Bond Donors 2
Hydrogen Bond Acceptors 7
logP 13.55
Molar Refractivity 231.07

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Updated at
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